The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction
المؤلفون المشاركون
Liu, Zhouying
Pu, Jielin
Zheng, Min
Liu, Nana
Hou, Cuihong
Zhang, Shu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aims.
The molecular mechanisms of Chinese traditional medicine Wenxin Keli (WXKL) were unknown.
This study was aimed at exploring the effects of WXKL on the gene expression profile and pathological alteration of rabbits with myocardial infarction.
Methods.
Twenty male adult rabbits were randomly divided into 4 groups: sham, model, WXKL, and captopril groups.
Model, WXKL, and captopril groups underwent the ligation of the left anterior descending coronary artery while sham group went through an identical procedure without ligation.
WXKL (817 mg/kg/d), captopril (8 mg/kg/d), and distilled water (to model and sham groups) were administered orally to each group.
After 4 weeks, the rabbits were examined with echocardiography and the hearts were taken for expression chip and pathological staining (H&E, Masson, and Tunel) studies.
Results.
The data revealed that WXKL downregulated genes associated with inflammation (CX3CR1, MRC1, and FPR1), apoptosis (CTSC and TTC5), and neurohumoral system (ACE and EDN1) and upregulated angiogenesis promoting genes such as RSPO3.
Moreover, the results also showed that WXKL improved cardiac function and prevented histopathological injury and apoptosis.
Conclusion.
The present study demonstrated that WXKL might play an important role in inhibiting inflammation, renin-angiotensin system, and apoptosis.
It might be a promising Chinese medicine in the treatment of patients with myocardial infarction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Min& Liu, Zhouying& Liu, Nana& Hou, Cuihong& Pu, Jielin& Zhang, Shu. 2016. The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103980
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Min…[et al.]. The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103980
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Min& Liu, Zhouying& Liu, Nana& Hou, Cuihong& Pu, Jielin& Zhang, Shu. The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103980
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103980
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر