The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction
Joint Authors
Liu, Zhouying
Pu, Jielin
Zheng, Min
Liu, Nana
Hou, Cuihong
Zhang, Shu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
The molecular mechanisms of Chinese traditional medicine Wenxin Keli (WXKL) were unknown.
This study was aimed at exploring the effects of WXKL on the gene expression profile and pathological alteration of rabbits with myocardial infarction.
Methods.
Twenty male adult rabbits were randomly divided into 4 groups: sham, model, WXKL, and captopril groups.
Model, WXKL, and captopril groups underwent the ligation of the left anterior descending coronary artery while sham group went through an identical procedure without ligation.
WXKL (817 mg/kg/d), captopril (8 mg/kg/d), and distilled water (to model and sham groups) were administered orally to each group.
After 4 weeks, the rabbits were examined with echocardiography and the hearts were taken for expression chip and pathological staining (H&E, Masson, and Tunel) studies.
Results.
The data revealed that WXKL downregulated genes associated with inflammation (CX3CR1, MRC1, and FPR1), apoptosis (CTSC and TTC5), and neurohumoral system (ACE and EDN1) and upregulated angiogenesis promoting genes such as RSPO3.
Moreover, the results also showed that WXKL improved cardiac function and prevented histopathological injury and apoptosis.
Conclusion.
The present study demonstrated that WXKL might play an important role in inhibiting inflammation, renin-angiotensin system, and apoptosis.
It might be a promising Chinese medicine in the treatment of patients with myocardial infarction.
American Psychological Association (APA)
Zheng, Min& Liu, Zhouying& Liu, Nana& Hou, Cuihong& Pu, Jielin& Zhang, Shu. 2016. The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103980
Modern Language Association (MLA)
Zheng, Min…[et al.]. The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103980
American Medical Association (AMA)
Zheng, Min& Liu, Zhouying& Liu, Nana& Hou, Cuihong& Pu, Jielin& Zhang, Shu. The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103980