Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia
المؤلفون المشاركون
Wu, Peng
Luo, Yuandai
Zhen, Lifang
Hu, Xianda
Shang, Ying
Liao, Yinuo
Xue, Huiyuan
Huang, Fukai
Xiao, Wei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Rannasangpei (RSNP) is used as a therapeutic agent in the treatment of cardiovascular diseases, neurological disorders, and neurodegeneration in China; however, its potential use in the treatment of vascular dementia (VD) was unclear.
In this study, our aim was to examine the neuroprotective effect of RSNP in a VD rat model, which was induced by permanent bilateral common carotid artery occlusion (2VO).
Four-week administration with two doses of RSNP was investigated in our study.
Severe cognitive deficit in the VD model, which was confirmed in Morris water maze (MWM) test, was significantly restored by the administration of RSNP.
ELISA revealed that the treatments with both doses of RSNP could reinstate the cholinergic activity in the VD animals by elevating the production of choline acetyltransferase (ChAT) and reducing the acetylcholinesterase (AChE); the treatment of RSNP could also reboot the level of superoxide dismutase (SOD) and decrease malondialdehyde (MDA).
Moreover, Western blot and quantitative PCR (Q-PCR) results indicated that the RSNP could suppress the apoptosis in the hippocampus of the VD animals by increasing the expression ratio of B-cell lymphoma-2 (Bcl-2) to Bcl-2-associated X protein (Bax).
These results suggested that RSNP might be a therapeutic agent in the treatment of vascular dementia in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Peng& Luo, Yuandai& Zhen, Lifang& Hu, Xianda& Shang, Ying& Liao, Yinuo…[et al.]. 2016. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Peng…[et al.]. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Peng& Luo, Yuandai& Zhen, Lifang& Hu, Xianda& Shang, Ying& Liao, Yinuo…[et al.]. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر