Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia
Joint Authors
Wu, Peng
Luo, Yuandai
Zhen, Lifang
Hu, Xianda
Shang, Ying
Liao, Yinuo
Xue, Huiyuan
Huang, Fukai
Xiao, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rannasangpei (RSNP) is used as a therapeutic agent in the treatment of cardiovascular diseases, neurological disorders, and neurodegeneration in China; however, its potential use in the treatment of vascular dementia (VD) was unclear.
In this study, our aim was to examine the neuroprotective effect of RSNP in a VD rat model, which was induced by permanent bilateral common carotid artery occlusion (2VO).
Four-week administration with two doses of RSNP was investigated in our study.
Severe cognitive deficit in the VD model, which was confirmed in Morris water maze (MWM) test, was significantly restored by the administration of RSNP.
ELISA revealed that the treatments with both doses of RSNP could reinstate the cholinergic activity in the VD animals by elevating the production of choline acetyltransferase (ChAT) and reducing the acetylcholinesterase (AChE); the treatment of RSNP could also reboot the level of superoxide dismutase (SOD) and decrease malondialdehyde (MDA).
Moreover, Western blot and quantitative PCR (Q-PCR) results indicated that the RSNP could suppress the apoptosis in the hippocampus of the VD animals by increasing the expression ratio of B-cell lymphoma-2 (Bcl-2) to Bcl-2-associated X protein (Bax).
These results suggested that RSNP might be a therapeutic agent in the treatment of vascular dementia in the future.
American Psychological Association (APA)
Wu, Peng& Luo, Yuandai& Zhen, Lifang& Hu, Xianda& Shang, Ying& Liao, Yinuo…[et al.]. 2016. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103988
Modern Language Association (MLA)
Wu, Peng…[et al.]. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103988
American Medical Association (AMA)
Wu, Peng& Luo, Yuandai& Zhen, Lifang& Hu, Xianda& Shang, Ying& Liao, Yinuo…[et al.]. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103988