Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial
المؤلفون المشاركون
Li, Yi
Zhang, Xinchao
Lin, Peihong
Qiu, Haibo
Wei, Jie
Cao, Yu
Pan, Shuming
Walline, Joseph
Qian, Chuanyun
Shan, Zhigang
Yu, XueZhong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The effect of Shenfu on biochemical parameters and survival during resuscitation in patients with septic shock was examined.
This was a multicenter, controlled, randomized, open-label trial carried out in 210 patients with septic shock from seven medical centers in China.
They were randomized to Shenfu or saline.
The primary outcome was lactate clearance.
The secondary outcomes were shock index normalization, dose of vasopressors, ICU stay, hospital stay, and mortality.
A total of 199 patients completed the trial.
Blood pressure, heart rate, and other routine lab tests showed no difference between the groups.
Lactate levels and lactate clearance were similar between the two groups.
Hospital and ICU stay were similar between the two groups.
When considering all patients, the 7- and 28-day mortality were similar between the two groups, but when considering only patients with lactate levels ≥4.5 mmol/L, the Shenfu group showed a better 7-day survival than the control group (7 days: 83.3% versus 54.5%, P = 0.034 ; 28 days: 72.7% versus 47.6%, P = 0.092 ).
Shenfu may improve the 7-day survival in patients with impaired lactate clearance (≥4.5 mmol/L), but the mechanism for this effect is unclear.
Additional studies are necessary to characterize the hemodynamic changes after Shenfu infusion.
This trial is registered with ChiCTR-TRC-11001369.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yi& Zhang, Xinchao& Lin, Peihong& Qiu, Haibo& Wei, Jie& Cao, Yu…[et al.]. 2016. Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103995
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yi…[et al.]. Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103995
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yi& Zhang, Xinchao& Lin, Peihong& Qiu, Haibo& Wei, Jie& Cao, Yu…[et al.]. Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103995
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103995
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر