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Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial
Joint Authors
Li, Yi
Zhang, Xinchao
Lin, Peihong
Qiu, Haibo
Wei, Jie
Cao, Yu
Pan, Shuming
Walline, Joseph
Qian, Chuanyun
Shan, Zhigang
Yu, XueZhong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The effect of Shenfu on biochemical parameters and survival during resuscitation in patients with septic shock was examined.
This was a multicenter, controlled, randomized, open-label trial carried out in 210 patients with septic shock from seven medical centers in China.
They were randomized to Shenfu or saline.
The primary outcome was lactate clearance.
The secondary outcomes were shock index normalization, dose of vasopressors, ICU stay, hospital stay, and mortality.
A total of 199 patients completed the trial.
Blood pressure, heart rate, and other routine lab tests showed no difference between the groups.
Lactate levels and lactate clearance were similar between the two groups.
Hospital and ICU stay were similar between the two groups.
When considering all patients, the 7- and 28-day mortality were similar between the two groups, but when considering only patients with lactate levels ≥4.5 mmol/L, the Shenfu group showed a better 7-day survival than the control group (7 days: 83.3% versus 54.5%, P = 0.034 ; 28 days: 72.7% versus 47.6%, P = 0.092 ).
Shenfu may improve the 7-day survival in patients with impaired lactate clearance (≥4.5 mmol/L), but the mechanism for this effect is unclear.
Additional studies are necessary to characterize the hemodynamic changes after Shenfu infusion.
This trial is registered with ChiCTR-TRC-11001369.
American Psychological Association (APA)
Li, Yi& Zhang, Xinchao& Lin, Peihong& Qiu, Haibo& Wei, Jie& Cao, Yu…[et al.]. 2016. Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103995
Modern Language Association (MLA)
Li, Yi…[et al.]. Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103995
American Medical Association (AMA)
Li, Yi& Zhang, Xinchao& Lin, Peihong& Qiu, Haibo& Wei, Jie& Cao, Yu…[et al.]. Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103995