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Preparative Purification of Bioactive Compounds from Flos Chrysanthemi Indici and Evaluation of Its Antiosteoporosis Effect
المؤلفون المشاركون
Li, Jia
Lin, Xiaosheng
Zhang, Yuping
Liu, Weicai
Mi, Xiaohui
Zhang, Jiquan
Su, Jiansheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
To understand the material basis and underlying molecular machinery of antiosteoporosis activity of the Flos Chrysanthemi Indici (FCI), the consequences of ethanol extract on the bone loss in mice induced due to ovariectomy (OVX) was evaluated.
Also, the antiosteoporosis fraction obtained from the FCI ethanol extract was isolated and purified using a preparative high-speed countercurrent chromatography (HSCCC).
The in vitro impact of the compounds was investigated on osteoblast proliferation and differentiation.
The results revealed that ethyl acetate fraction with robust in vivo antiosteoporosis activity was obtained.
The important compounds purified by HSCCC using gradient elution system included acacetin, apigenin, luteolin, and linarin.
The four compounds enhanced the differentiation and proliferation of osteoblasts in MC3T3-E1 cells.
They also augmented the mRNA levels of runt-related transcription factor 2 (Runx2), osteocalcin (OCN), osteopontin (OPN), and type I collagen (COL I).
The AKT signaling pathway was also activated in MC3T3-E1 cells by the four compounds.
The present study demonstrated that the antiosteoporosis effects of FCI did not depend on a single component, and HSCCC efficiently isolated and purified the antiosteoporosis bioactive compounds from FCI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jia& Lin, Xiaosheng& Zhang, Yuping& Liu, Weicai& Mi, Xiaohui& Zhang, Jiquan…[et al.]. 2016. Preparative Purification of Bioactive Compounds from Flos Chrysanthemi Indici and Evaluation of Its Antiosteoporosis Effect. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103997
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jia…[et al.]. Preparative Purification of Bioactive Compounds from Flos Chrysanthemi Indici and Evaluation of Its Antiosteoporosis Effect. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1103997
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jia& Lin, Xiaosheng& Zhang, Yuping& Liu, Weicai& Mi, Xiaohui& Zhang, Jiquan…[et al.]. Preparative Purification of Bioactive Compounds from Flos Chrysanthemi Indici and Evaluation of Its Antiosteoporosis Effect. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103997
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103997
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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