![](/images/graphics-bg.png)
Protective Effect of Yinhua Miyanling Tablet on Lipopolysaccharide-Induced Inflammation through Suppression of NLRP3Caspase-1 Inflammasome in Human Peripheral Blood Mononuclear Cells
المؤلفون المشاركون
Xiong, Lingxin
Liu, Chuangui
Zhang, Xiaotian
Wang, Fang
Zhang, Chao
Sai, Jingying
Zheng, Jingtong
Lu, Yanjiao
Wang, Guoqiang
Wang, Yawei
Wang, Ting
Guan, Xuewa
Chen, Fang
Fang, Keyong
Lu, Junying
Zhu, Hailin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Yinhua Miyanling Tablet (YMT), the Chinese formula, has long been administrated in clinical practice for the treatment of acute pyelonephritis and acute urocystitis.
In the current study, we aimed to investigate the anti-inflammatory effect of YMT in vitro and to evaluate the association between anti-inflammation and innate immune response.
Human peripheral blood mononuclear cells (PBMCs) were isolated using Ficoll density gradient centrifugation and then were stimulated by Lipopolysaccharide (LPS).
The differential gene expression of inflammation-related genes after drug administration was assessed using PCR array, and the protein levels of differential genes were measured by ELISA and Western blot.
The result showed that YMT significantly inhibited the expression of NLRP3, Caspase-1, and the downstream cytokine IL-1β and suppressed the production of inflammatory mediators TNF-α, IL-6, IL-10, and MCP-1 in a dose-dependent manner compared to the LPS group P < 0.01 .
The finding indicated that YMT exhibited anti-inflammatory effect in vitro by suppressing the NLRP3/Caspase-1 inflammasome, and that may have therapeutic potential for the treatment of inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sai, Jingying& Xiong, Lingxin& Zheng, Jingtong& Liu, Chuangui& Lu, Yanjiao& Wang, Guoqiang…[et al.]. 2016. Protective Effect of Yinhua Miyanling Tablet on Lipopolysaccharide-Induced Inflammation through Suppression of NLRP3Caspase-1 Inflammasome in Human Peripheral Blood Mononuclear Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104017
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sai, Jingying…[et al.]. Protective Effect of Yinhua Miyanling Tablet on Lipopolysaccharide-Induced Inflammation through Suppression of NLRP3Caspase-1 Inflammasome in Human Peripheral Blood Mononuclear Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104017
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sai, Jingying& Xiong, Lingxin& Zheng, Jingtong& Liu, Chuangui& Lu, Yanjiao& Wang, Guoqiang…[et al.]. Protective Effect of Yinhua Miyanling Tablet on Lipopolysaccharide-Induced Inflammation through Suppression of NLRP3Caspase-1 Inflammasome in Human Peripheral Blood Mononuclear Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104017
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104017
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)