Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis
المؤلفون المشاركون
Nascimento, F. R. F.
Guerra, Rosane Nassar Meireles
Silva, Lucilene Amorim
Barroqueiro, Elizabeth S. B.
Prado, Dayanna S.
Barcellos, Priscila S.
Silva, Tonicley A.
Pereira, Wanderson S.
Maciel, Márcia C. G.
Barroqueiro, Rodrigo B.
Gonçalves, Azizedite G.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Attalea speciosa syn Orbignya phalerata Mart.
(babassu) has been used in the treatment of inflammatory and infectious diseases.
Aim of the study.
To investigate the antimicrobial and immunological activity of babassu mesocarp extract (EE).
Material and Methods.
The in vitro antimicrobial activity was evaluated by disk diffusion assay and by determination of the minimum inhibitory concentration (MIC) to Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA).
The flavonoids and phenolic acids content were determined by chromatography.
The in vivo assays were performed in Swiss mice submitted to sepsis by cecal ligation and puncture (CLP).
The mice received EE subcutaneously (125 or 250 mg/Kg), 6 hours after the CLP.
The number of lymphoid cells was quantified and the cytokines production was determined by ELISA after 12 h.
Results.
EE was effective as antimicrobial to E.
faecalis, S.
aureus, and MRSA.
EE is rich in phenolic acids, a class of compounds with antimicrobial and immunological activity.
An increased survival can be observed in those groups, possibly due to a significant inhibition of TNF-α and IL-6.
Conclusions.
The EE showed specific antimicrobial activity in vitro and an important antiseptic effect in vivo possibly due to the antimicrobial and immunomodulatory activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barroqueiro, Elizabeth S. B.& Prado, Dayanna S.& Barcellos, Priscila S.& Silva, Tonicley A.& Pereira, Wanderson S.& Silva, Lucilene Amorim…[et al.]. 2016. Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104023
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barroqueiro, Elizabeth S. B.…[et al.]. Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104023
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barroqueiro, Elizabeth S. B.& Prado, Dayanna S.& Barcellos, Priscila S.& Silva, Tonicley A.& Pereira, Wanderson S.& Silva, Lucilene Amorim…[et al.]. Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104023
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104023
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر