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Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis
Joint Authors
Nascimento, F. R. F.
Guerra, Rosane Nassar Meireles
Silva, Lucilene Amorim
Barroqueiro, Elizabeth S. B.
Prado, Dayanna S.
Barcellos, Priscila S.
Silva, Tonicley A.
Pereira, Wanderson S.
Maciel, Márcia C. G.
Barroqueiro, Rodrigo B.
Gonçalves, Azizedite G.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Attalea speciosa syn Orbignya phalerata Mart.
(babassu) has been used in the treatment of inflammatory and infectious diseases.
Aim of the study.
To investigate the antimicrobial and immunological activity of babassu mesocarp extract (EE).
Material and Methods.
The in vitro antimicrobial activity was evaluated by disk diffusion assay and by determination of the minimum inhibitory concentration (MIC) to Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA).
The flavonoids and phenolic acids content were determined by chromatography.
The in vivo assays were performed in Swiss mice submitted to sepsis by cecal ligation and puncture (CLP).
The mice received EE subcutaneously (125 or 250 mg/Kg), 6 hours after the CLP.
The number of lymphoid cells was quantified and the cytokines production was determined by ELISA after 12 h.
Results.
EE was effective as antimicrobial to E.
faecalis, S.
aureus, and MRSA.
EE is rich in phenolic acids, a class of compounds with antimicrobial and immunological activity.
An increased survival can be observed in those groups, possibly due to a significant inhibition of TNF-α and IL-6.
Conclusions.
The EE showed specific antimicrobial activity in vitro and an important antiseptic effect in vivo possibly due to the antimicrobial and immunomodulatory activity.
American Psychological Association (APA)
Barroqueiro, Elizabeth S. B.& Prado, Dayanna S.& Barcellos, Priscila S.& Silva, Tonicley A.& Pereira, Wanderson S.& Silva, Lucilene Amorim…[et al.]. 2016. Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104023
Modern Language Association (MLA)
Barroqueiro, Elizabeth S. B.…[et al.]. Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104023
American Medical Association (AMA)
Barroqueiro, Elizabeth S. B.& Prado, Dayanna S.& Barcellos, Priscila S.& Silva, Tonicley A.& Pereira, Wanderson S.& Silva, Lucilene Amorim…[et al.]. Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104023