A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility
المؤلفون المشاركون
Liu, Huiping
Zeng, Liuting
Yang, Kailin
Zhang, Guomin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Aim.
To explore the pharmacological mechanism of Xiaoyao powder (XYP) on anovulatory infertility by a network pharmacology approach.
Method.
Collect XYP’s active compounds by traditional Chinese medicine (TCM) databases, and input them into PharmMapper to get their targets.
Then note these targets by Kyoto Encyclopedia of Genes and Genomes (KEGG) and filter out targets that can be noted by human signal pathway.
Get the information of modern pharmacology of active compounds and recipe’s traditional effects through databases.
Acquire infertility targets by Therapeutic Target Database (TTD).
Collect the interactions of all the targets and other human proteins via String and INACT.
Put all the targets into the Database for Annotation, Visualization, and Integrated Discovery (DAVID) to do GO enrichment analysis.
Finally, draw the network by Cytoscape by the information above.
Result.
Six network pictures and two GO enrichment analysis pictures are visualized.
Conclusion.
According to this network pharmacology approach some signal pathways of XYP acting on infertility are found for the first time.
Some biological processes can also be identified as XYP’s effects on anovulatory infertility.
We believe that evaluating the efficacy of TCM recipes and uncovering the pharmacological mechanism on a systematic level will be a significant method for future studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Huiping& Zeng, Liuting& Yang, Kailin& Zhang, Guomin. 2016. A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Huiping…[et al.]. A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Huiping& Zeng, Liuting& Yang, Kailin& Zhang, Guomin. A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر