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A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility
Joint Authors
Liu, Huiping
Zeng, Liuting
Yang, Kailin
Zhang, Guomin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aim.
To explore the pharmacological mechanism of Xiaoyao powder (XYP) on anovulatory infertility by a network pharmacology approach.
Method.
Collect XYP’s active compounds by traditional Chinese medicine (TCM) databases, and input them into PharmMapper to get their targets.
Then note these targets by Kyoto Encyclopedia of Genes and Genomes (KEGG) and filter out targets that can be noted by human signal pathway.
Get the information of modern pharmacology of active compounds and recipe’s traditional effects through databases.
Acquire infertility targets by Therapeutic Target Database (TTD).
Collect the interactions of all the targets and other human proteins via String and INACT.
Put all the targets into the Database for Annotation, Visualization, and Integrated Discovery (DAVID) to do GO enrichment analysis.
Finally, draw the network by Cytoscape by the information above.
Result.
Six network pictures and two GO enrichment analysis pictures are visualized.
Conclusion.
According to this network pharmacology approach some signal pathways of XYP acting on infertility are found for the first time.
Some biological processes can also be identified as XYP’s effects on anovulatory infertility.
We believe that evaluating the efficacy of TCM recipes and uncovering the pharmacological mechanism on a systematic level will be a significant method for future studies.
American Psychological Association (APA)
Liu, Huiping& Zeng, Liuting& Yang, Kailin& Zhang, Guomin. 2016. A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104032
Modern Language Association (MLA)
Liu, Huiping…[et al.]. A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104032
American Medical Association (AMA)
Liu, Huiping& Zeng, Liuting& Yang, Kailin& Zhang, Guomin. A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104032