Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I)
المؤلفون المشاركون
Zhou, Li
Huang, Qiuling
Wang, Rong
Zhou, Jie
Ma, Aicui
Chong, Liming
Wu, Yubing
Wang, Yong
Xu, Li
Chen, Ying
Jia, Yuling
Gui, Bo
Sun, Zuyue
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
This study was aimed to investigate the reproductive toxicity of Zishen Yutai Pill (ZYP) on fertility and early embryonic development in rats.
Methods.
SD rats were randomly divided into 5 groups: vehicle control group (distilled water, i.g.), positive control group (80 mg/kg of cyclophosphamide, i.p.), and three ZYP-treated groups (3, 6, and 12 g/kg/d, i.e., 12x, 24x, and 48x clinical doses, i.g.).
The high dose was set as the maximum gavage dosage.
Results.
Cyclophosphamide showed diverse hazards, such as decreased weight of male reproductive organs and sperm density (P<0.05).
However, there were no obvious effects of ZYP on physical signs, animal behavior, and survival rate, as well as on weight and food intake during the premating and gestation periods.
Importantly, there were no significant adverse effects of ZYP on indexes of copulation, fecundity and fertility indexes, weights and coefficients of male reproductive organs, epididymal sperm number and motility, estrous cycle, preimplantation loss rate, and implantation rate.
Besides, the numbers of live and resorbed fetuses per litter were not significantly altered.
Conclusions.
ZYP had no reproductive toxicities on fertility and early embryonic development in rats at 48x equivalent clinical doses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Li& Huang, Qiuling& Wang, Rong& Zhou, Jie& Ma, Aicui& Chong, Liming…[et al.]. 2016. Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I). Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104053
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Li…[et al.]. Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I). Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104053
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Li& Huang, Qiuling& Wang, Rong& Zhou, Jie& Ma, Aicui& Chong, Liming…[et al.]. Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I). Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104053
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104053
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر