Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I)
Joint Authors
Zhou, Li
Huang, Qiuling
Wang, Rong
Zhou, Jie
Ma, Aicui
Chong, Liming
Wu, Yubing
Wang, Yong
Xu, Li
Chen, Ying
Jia, Yuling
Gui, Bo
Sun, Zuyue
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
This study was aimed to investigate the reproductive toxicity of Zishen Yutai Pill (ZYP) on fertility and early embryonic development in rats.
Methods.
SD rats were randomly divided into 5 groups: vehicle control group (distilled water, i.g.), positive control group (80 mg/kg of cyclophosphamide, i.p.), and three ZYP-treated groups (3, 6, and 12 g/kg/d, i.e., 12x, 24x, and 48x clinical doses, i.g.).
The high dose was set as the maximum gavage dosage.
Results.
Cyclophosphamide showed diverse hazards, such as decreased weight of male reproductive organs and sperm density (P<0.05).
However, there were no obvious effects of ZYP on physical signs, animal behavior, and survival rate, as well as on weight and food intake during the premating and gestation periods.
Importantly, there were no significant adverse effects of ZYP on indexes of copulation, fecundity and fertility indexes, weights and coefficients of male reproductive organs, epididymal sperm number and motility, estrous cycle, preimplantation loss rate, and implantation rate.
Besides, the numbers of live and resorbed fetuses per litter were not significantly altered.
Conclusions.
ZYP had no reproductive toxicities on fertility and early embryonic development in rats at 48x equivalent clinical doses.
American Psychological Association (APA)
Zhou, Li& Huang, Qiuling& Wang, Rong& Zhou, Jie& Ma, Aicui& Chong, Liming…[et al.]. 2016. Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I). Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104053
Modern Language Association (MLA)
Zhou, Li…[et al.]. Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I). Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104053
American Medical Association (AMA)
Zhou, Li& Huang, Qiuling& Wang, Rong& Zhou, Jie& Ma, Aicui& Chong, Liming…[et al.]. Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I). Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104053