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Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays
المؤلفون المشاركون
Liu, Hui-Kang
Lee, Yu-Ching
Lin, Yun-Lian
Tsay, Huey-Jen
Huang, Hsiu-Chen
Chang, Chia-Chuan
Yuan, Wei
Sun, Wan-Hua
Juan, Yi-Chen
Liu, Ren-Shyan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Radix Paeoniae Rubra (Chi Shao) contains several phytochemicals with hypoglycemic actions.
Current research aims to explore potential insulinotropic effects and long-term therapeutic efficacy of such herb against type 2 diabetes.
Methods.
Composition analysis for the ethanol extract (PRExt) was executed by high performance liquid chromatography.
Polyphenol-enriched fraction was characterized by high pressure size exclusion chromatography.
Multiple cell platforms were employed to evaluate hypoglycemic bioactivities.
In animal experiments, blood glucose, the homeostasis model assessment (HOMA)-index assessment, glucose tolerance test, and in vivo glucose uptake were all measured.
Additional effects of PRExt on obesity and hepatic steatosis were evaluated by serum and histological analysis.
Results.
PRExt provides multiple hypoglycemic effects including the enhancement of glucose-mediated insulin secretion.
Pentagalloylglucose and polyphenol-enriched fraction are two insulinotropic constituents.
Moreover, PRExt intraperitoneal injection causes acute hypoglycemic effects on fasted db/db mice.
Oral administration of PRExt (200 mg/kg b.w.) gradually reduces blood glucose in db/db mice to the level similar to that in C57J/B6 mice after 30 days.
The improvement of glucose intolerance, HOMA-index, and in vivo glucose uptake is evident in addition to the weight loss effect and attenuation of hepatic steatosis.
Conclusion.
PRExt is an effective antidiabetic herbal extract with multiple hypoglycemic bioactivities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Chia-Chuan& Yuan, Wei& Lin, Yun-Lian& Liu, Ren-Shyan& Juan, Yi-Chen& Sun, Wan-Hua…[et al.]. 2016. Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104061
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Chia-Chuan…[et al.]. Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104061
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Chia-Chuan& Yuan, Wei& Lin, Yun-Lian& Liu, Ren-Shyan& Juan, Yi-Chen& Sun, Wan-Hua…[et al.]. Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104061
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104061
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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