Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays
Joint Authors
Liu, Hui-Kang
Lee, Yu-Ching
Lin, Yun-Lian
Tsay, Huey-Jen
Huang, Hsiu-Chen
Chang, Chia-Chuan
Yuan, Wei
Sun, Wan-Hua
Juan, Yi-Chen
Liu, Ren-Shyan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Radix Paeoniae Rubra (Chi Shao) contains several phytochemicals with hypoglycemic actions.
Current research aims to explore potential insulinotropic effects and long-term therapeutic efficacy of such herb against type 2 diabetes.
Methods.
Composition analysis for the ethanol extract (PRExt) was executed by high performance liquid chromatography.
Polyphenol-enriched fraction was characterized by high pressure size exclusion chromatography.
Multiple cell platforms were employed to evaluate hypoglycemic bioactivities.
In animal experiments, blood glucose, the homeostasis model assessment (HOMA)-index assessment, glucose tolerance test, and in vivo glucose uptake were all measured.
Additional effects of PRExt on obesity and hepatic steatosis were evaluated by serum and histological analysis.
Results.
PRExt provides multiple hypoglycemic effects including the enhancement of glucose-mediated insulin secretion.
Pentagalloylglucose and polyphenol-enriched fraction are two insulinotropic constituents.
Moreover, PRExt intraperitoneal injection causes acute hypoglycemic effects on fasted db/db mice.
Oral administration of PRExt (200 mg/kg b.w.) gradually reduces blood glucose in db/db mice to the level similar to that in C57J/B6 mice after 30 days.
The improvement of glucose intolerance, HOMA-index, and in vivo glucose uptake is evident in addition to the weight loss effect and attenuation of hepatic steatosis.
Conclusion.
PRExt is an effective antidiabetic herbal extract with multiple hypoglycemic bioactivities.
American Psychological Association (APA)
Chang, Chia-Chuan& Yuan, Wei& Lin, Yun-Lian& Liu, Ren-Shyan& Juan, Yi-Chen& Sun, Wan-Hua…[et al.]. 2016. Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104061
Modern Language Association (MLA)
Chang, Chia-Chuan…[et al.]. Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104061
American Medical Association (AMA)
Chang, Chia-Chuan& Yuan, Wei& Lin, Yun-Lian& Liu, Ren-Shyan& Juan, Yi-Chen& Sun, Wan-Hua…[et al.]. Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104061