Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin

المؤلفون المشاركون

Li, Yuan
Xie, Yanming
Wang, Lianxin
Zhang, Yingying
Chai, Yan
Gu, Hao

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-03-16

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

The aim of this study is to examine and compare the similarities and differences between active components of S.

miltiorrhiza depside salt and aspirin using perspective of pharmacological molecular networks.

Active components of S.

miltiorrhiza depside salt and aspirin’s related genes were identified via the STITCH4.0 and GeneCards Database.

A text search engine (Agilent Literature Search 2.71) and MCODE software were applied to construct network and divide modules, respectively.

Finally, 32, 2, and 28 overlapping genes, modules, and pathways were identified between active components of S.

miltiorrhiza depside salt and aspirin.

A multidimensional framework of drug network showed that two networks reflected commonly in human aortic endothelial cells and atherosclerosis process.

Aspirin plays a more important role in metabolism, such as the well-known AA metabolism pathway and other lipid or carbohydrate metabolism pathways.

S.

miltiorrhiza depside salt still plays a regulatory role in type II diabetes mellitus, insulin resistance, and adipocytokine signaling pathway.

Therefore, this study suggests that aspirin combined with S.

miltiorrhiza depside salt may be more efficient in treatment of CHD patients, especially those with diabetes mellitus or hyperlipidemia.

Further clinical trials to confirm this hypothesis are still needed.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Yuan& Xie, Yanming& Wang, Lianxin& Zhang, Yingying& Gu, Hao& Chai, Yan. 2016. Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104070

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Yuan…[et al.]. Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104070

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Yuan& Xie, Yanming& Wang, Lianxin& Zhang, Yingying& Gu, Hao& Chai, Yan. Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104070

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1104070