Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin
Joint Authors
Li, Yuan
Xie, Yanming
Wang, Lianxin
Zhang, Yingying
Chai, Yan
Gu, Hao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study is to examine and compare the similarities and differences between active components of S.
miltiorrhiza depside salt and aspirin using perspective of pharmacological molecular networks.
Active components of S.
miltiorrhiza depside salt and aspirin’s related genes were identified via the STITCH4.0 and GeneCards Database.
A text search engine (Agilent Literature Search 2.71) and MCODE software were applied to construct network and divide modules, respectively.
Finally, 32, 2, and 28 overlapping genes, modules, and pathways were identified between active components of S.
miltiorrhiza depside salt and aspirin.
A multidimensional framework of drug network showed that two networks reflected commonly in human aortic endothelial cells and atherosclerosis process.
Aspirin plays a more important role in metabolism, such as the well-known AA metabolism pathway and other lipid or carbohydrate metabolism pathways.
S.
miltiorrhiza depside salt still plays a regulatory role in type II diabetes mellitus, insulin resistance, and adipocytokine signaling pathway.
Therefore, this study suggests that aspirin combined with S.
miltiorrhiza depside salt may be more efficient in treatment of CHD patients, especially those with diabetes mellitus or hyperlipidemia.
Further clinical trials to confirm this hypothesis are still needed.
American Psychological Association (APA)
Li, Yuan& Xie, Yanming& Wang, Lianxin& Zhang, Yingying& Gu, Hao& Chai, Yan. 2016. Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104070
Modern Language Association (MLA)
Li, Yuan…[et al.]. Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104070
American Medical Association (AMA)
Li, Yuan& Xie, Yanming& Wang, Lianxin& Zhang, Yingying& Gu, Hao& Chai, Yan. Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104070