Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators
المؤلفون المشاركون
Santin, José Roberto
da Silva, Luisa Mota
Farias, Jaime Antonio Machado
Boeing, Thaise
Somensi, Lincon Bordignon
Beber, Ana Paula
Cury, Benhur Judah
Faloni de Andrade, Sérgio
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-25
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Achyrocline satureioides is a South American herb used to treat inflammatory and gastrointestinal diseases.
This study evaluated intestinal anti-inflammatory effects of the hydroalcoholic extract of inflorescences of satureioides (HEAS) in dextran sulfate sodium (DSS) induced colitis in mice.
Mice were orally treated with vehicle, 5-aminosalicylic acid (100 mg/kg), or HEAS (1–100 mg/kg).
Clinical signs of colitis and colonic histopathological parameters were evaluated, along with the determination of levels of reduced glutathione and lipid hydroperoxide (LOOH), the superoxide dismutase (SOD), and myeloperoxidase (MPO) activity in colon.
The colonic content of cytokines (TNF, IL-4, IL-6, and IL-10) was measured.
Additionally, the effects of the extract on nitric oxide (NO) release by lipopolysaccharide (LPS) stimulated macrophages and diphenylpicrylhydrazyl levels were determined.
Mucin levels and SOD activity, as well as the LOOH, MPO, TNF, and IL-6 accumulation in colon tissues, were normalized by the HEAS administration.
In addition, the extract elicited an increase in IL-4 and IL-10 levels in colon.
NO release by macrophages was inhibited by HEAS and its scavenger activity was confirmed.
Together these results suggest that preparations obtained from inflorescences from A.
satureioides could be used in treatment for IBD.
Besides, this work corroborates the popular use of A.
satureioides in inflammatory disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
da Silva, Luisa Mota& Farias, Jaime Antonio Machado& Boeing, Thaise& Somensi, Lincon Bordignon& Beber, Ana Paula& Cury, Benhur Judah…[et al.]. 2016. Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104074
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
da Silva, Luisa Mota…[et al.]. Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104074
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
da Silva, Luisa Mota& Farias, Jaime Antonio Machado& Boeing, Thaise& Somensi, Lincon Bordignon& Beber, Ana Paula& Cury, Benhur Judah…[et al.]. Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104074
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104074
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر