Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators
Joint Authors
Santin, José Roberto
da Silva, Luisa Mota
Farias, Jaime Antonio Machado
Boeing, Thaise
Somensi, Lincon Bordignon
Beber, Ana Paula
Cury, Benhur Judah
Faloni de Andrade, Sérgio
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Achyrocline satureioides is a South American herb used to treat inflammatory and gastrointestinal diseases.
This study evaluated intestinal anti-inflammatory effects of the hydroalcoholic extract of inflorescences of satureioides (HEAS) in dextran sulfate sodium (DSS) induced colitis in mice.
Mice were orally treated with vehicle, 5-aminosalicylic acid (100 mg/kg), or HEAS (1–100 mg/kg).
Clinical signs of colitis and colonic histopathological parameters were evaluated, along with the determination of levels of reduced glutathione and lipid hydroperoxide (LOOH), the superoxide dismutase (SOD), and myeloperoxidase (MPO) activity in colon.
The colonic content of cytokines (TNF, IL-4, IL-6, and IL-10) was measured.
Additionally, the effects of the extract on nitric oxide (NO) release by lipopolysaccharide (LPS) stimulated macrophages and diphenylpicrylhydrazyl levels were determined.
Mucin levels and SOD activity, as well as the LOOH, MPO, TNF, and IL-6 accumulation in colon tissues, were normalized by the HEAS administration.
In addition, the extract elicited an increase in IL-4 and IL-10 levels in colon.
NO release by macrophages was inhibited by HEAS and its scavenger activity was confirmed.
Together these results suggest that preparations obtained from inflorescences from A.
satureioides could be used in treatment for IBD.
Besides, this work corroborates the popular use of A.
satureioides in inflammatory disorders.
American Psychological Association (APA)
da Silva, Luisa Mota& Farias, Jaime Antonio Machado& Boeing, Thaise& Somensi, Lincon Bordignon& Beber, Ana Paula& Cury, Benhur Judah…[et al.]. 2016. Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104074
Modern Language Association (MLA)
da Silva, Luisa Mota…[et al.]. Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104074
American Medical Association (AMA)
da Silva, Luisa Mota& Farias, Jaime Antonio Machado& Boeing, Thaise& Somensi, Lincon Bordignon& Beber, Ana Paula& Cury, Benhur Judah…[et al.]. Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104074