Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction
المؤلفون المشاركون
Yu, Tian
Guo, Xiaoheng
Zhang, Zhen
Liu, Rong
Zou, Liang
Fu, Jia
Shi, Zheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
To evaluate the efficacy and safety of ligustrazine in the treatment of cerebral infarction.
Methods.
A systematic literature search was conducted in 6 databases until 30 June 2016 to identify randomized controlled trials (RCTs) of ligustrazine in the treatment of cerebral infarction.
The quality of all the included studies was evaluated.
All data were analyzed by Review Manager 5.1 Software.
Results.
19 RCTs totally involving 1969 patients were included.
The primary outcome measures were Neurological Deficit Score (NDS) and clinical effective rate.
The secondary outcome measure was adverse events.
Meta-analysis showed that ligustrazine could improve clinical efficacy and NDS of cerebral infarction with [OR = 3.60, 95% CI (2.72, 4.78), P < 0.00001 ] and [WMD = −3.87, 95% CI (−4.78, −2.95), P < 0.00001 ].
Moreover, ligustrazine in treatment group exerted better clinical effects in improving the Blood Rheology Index (BRI) in patients compared with control group.
Ten trials contained safety assessments and stated that no obvious side effects were found.
Conclusions.
Ligustrazine demonstrated definite clinical efficacy for cerebral infarction, and it can also improve NDS in patients without obvious adverse events.
However, due to the existing low-quality research, more large-scale and multicentric RCTs are required to provide clear evidence for its clinical efficacy in the near future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Tian& Guo, Xiaoheng& Zhang, Zhen& Liu, Rong& Zou, Liang& Fu, Jia…[et al.]. 2016. Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104086
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Tian…[et al.]. Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104086
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Tian& Guo, Xiaoheng& Zhang, Zhen& Liu, Rong& Zou, Liang& Fu, Jia…[et al.]. Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104086
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104086
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر