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Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction
Joint Authors
Yu, Tian
Guo, Xiaoheng
Zhang, Zhen
Liu, Rong
Zou, Liang
Fu, Jia
Shi, Zheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
To evaluate the efficacy and safety of ligustrazine in the treatment of cerebral infarction.
Methods.
A systematic literature search was conducted in 6 databases until 30 June 2016 to identify randomized controlled trials (RCTs) of ligustrazine in the treatment of cerebral infarction.
The quality of all the included studies was evaluated.
All data were analyzed by Review Manager 5.1 Software.
Results.
19 RCTs totally involving 1969 patients were included.
The primary outcome measures were Neurological Deficit Score (NDS) and clinical effective rate.
The secondary outcome measure was adverse events.
Meta-analysis showed that ligustrazine could improve clinical efficacy and NDS of cerebral infarction with [OR = 3.60, 95% CI (2.72, 4.78), P < 0.00001 ] and [WMD = −3.87, 95% CI (−4.78, −2.95), P < 0.00001 ].
Moreover, ligustrazine in treatment group exerted better clinical effects in improving the Blood Rheology Index (BRI) in patients compared with control group.
Ten trials contained safety assessments and stated that no obvious side effects were found.
Conclusions.
Ligustrazine demonstrated definite clinical efficacy for cerebral infarction, and it can also improve NDS in patients without obvious adverse events.
However, due to the existing low-quality research, more large-scale and multicentric RCTs are required to provide clear evidence for its clinical efficacy in the near future.
American Psychological Association (APA)
Yu, Tian& Guo, Xiaoheng& Zhang, Zhen& Liu, Rong& Zou, Liang& Fu, Jia…[et al.]. 2016. Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104086
Modern Language Association (MLA)
Yu, Tian…[et al.]. Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104086
American Medical Association (AMA)
Yu, Tian& Guo, Xiaoheng& Zhang, Zhen& Liu, Rong& Zou, Liang& Fu, Jia…[et al.]. Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104086