The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture
المؤلفون المشاركون
Tamadon, Amin
Ma, Shulan
Wang, Xun
Huang, Yongheng
Yuan, Shiwen
Feng, Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Hormone replacement therapy is the principal treatment for perimenopausal affective disorders which can cause severe side effects.
The present study compared the effects of electroacupuncture (EA) and estradiol treatment on perimenopausal affective disorders at the behavioral and cellular levels.
In this randomized experimental in vivo study, adult female rats were divided into intact, ovariectomy, chronic unpredictable stress (CUS), and ovariectomy and CUS combination groups.
After week 6, all groups were subdivided to three subgroups of control, EA, and estradiol treatment.
The behavioral parameters in the open field and the elevated plus maze tests were assessed before and after treatments.
Alterations of serum steroid hormones and changes of estradiol receptor-α (ER-α) immunofluorescence neurons in the hippocampus sections were evaluated.
EA treatment caused more antianxiety effects than estradiol treatment in CUS group (P<0.05).
Notably, estradiol and EA treatments had better significant behavioral effects when the models were not estrogen-deficient.
Importantly, within each group, compared to the control group, the numbers of ER-α-positive neurons were significantly larger in EA subgroups.
Therefore, EA had antianxiety effects on perimenopausal affective disorders caused by CUS but not by estrogen deficiency and upregulation of hippocampus ER-α neurons may contribute to its mechanism of action.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xun& Huang, Yongheng& Yuan, Shiwen& Tamadon, Amin& Ma, Shulan& Feng, Yi. 2016. The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xun…[et al.]. The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xun& Huang, Yongheng& Yuan, Shiwen& Tamadon, Amin& Ma, Shulan& Feng, Yi. The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر