The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture
Joint Authors
Tamadon, Amin
Ma, Shulan
Wang, Xun
Huang, Yongheng
Yuan, Shiwen
Feng, Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hormone replacement therapy is the principal treatment for perimenopausal affective disorders which can cause severe side effects.
The present study compared the effects of electroacupuncture (EA) and estradiol treatment on perimenopausal affective disorders at the behavioral and cellular levels.
In this randomized experimental in vivo study, adult female rats were divided into intact, ovariectomy, chronic unpredictable stress (CUS), and ovariectomy and CUS combination groups.
After week 6, all groups were subdivided to three subgroups of control, EA, and estradiol treatment.
The behavioral parameters in the open field and the elevated plus maze tests were assessed before and after treatments.
Alterations of serum steroid hormones and changes of estradiol receptor-α (ER-α) immunofluorescence neurons in the hippocampus sections were evaluated.
EA treatment caused more antianxiety effects than estradiol treatment in CUS group (P<0.05).
Notably, estradiol and EA treatments had better significant behavioral effects when the models were not estrogen-deficient.
Importantly, within each group, compared to the control group, the numbers of ER-α-positive neurons were significantly larger in EA subgroups.
Therefore, EA had antianxiety effects on perimenopausal affective disorders caused by CUS but not by estrogen deficiency and upregulation of hippocampus ER-α neurons may contribute to its mechanism of action.
American Psychological Association (APA)
Wang, Xun& Huang, Yongheng& Yuan, Shiwen& Tamadon, Amin& Ma, Shulan& Feng, Yi. 2016. The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104177
Modern Language Association (MLA)
Wang, Xun…[et al.]. The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104177
American Medical Association (AMA)
Wang, Xun& Huang, Yongheng& Yuan, Shiwen& Tamadon, Amin& Ma, Shulan& Feng, Yi. The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104177