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A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model
المؤلفون المشاركون
Lee, Hye Won
Lee, Jin-Seok
Kim, Hyeong-Geug
Kim, Hyo-Seon
Lee, Sung-Bae
Im, Hwi-Jin
Kim, Won-Yong
Lee, Dong-Soo
Son, Chang Gue
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We aimed to evaluate the antihepatofibrotic effects of CGXII, an aqueous extract which is composed of A.
iwayomogi, A.
xanthioides, and S.
miltiorrhiza, against dimethylnitrosamine- (DMN-) induced hepatofibrosis.
Male Sprague Dawley rats were intraperitoneally injected with 10 mg/kg of DMN for 4 weeks (three consecutive days weekly).
Rats were orally given distilled water, CGXII (50 or 100 mg/kg), or dimethyl dimethoxy biphenyl dicarboxylate (50 mg/kg) daily.
DMN injection caused substantial alteration of total body weight and liver and spleen mass, whereas they were notably normalized by CGXII.
CGXII treatment also markedly attenuated the elevation of serum aspartate aminotransferase and alanine aminotransferase levels, hepatic lipid peroxidation, and protein carbonyl contents.
Collagen accumulation in hepatic tissue evidenced by histopathological analysis and quantitative assessment of hepatic hydroxyproline was ameliorated by CGXII.
Immunohistochemistry analysis revealed decreased α-smooth muscle actin supporting the antihepatofibrotic effect of CGXII.
The profibrogenic cytokines transforming growth factor-β, platelet-derived growth factor-β, and connective tissue growth factor were increased by DMN injection.
Administration of CGXII normalized the protein and gene expression levels of these cytokines.
Our findings suggest that CGXII lowers the levels of profibrogenic cytokines and thereby exerts antifibrotic effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Hyo-Seon& Kim, Hyeong-Geug& Lee, Hye Won& Lee, Sung-Bae& Lee, Jin-Seok& Im, Hwi-Jin…[et al.]. 2016. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104190
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Hyo-Seon…[et al.]. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1104190
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Hyo-Seon& Kim, Hyeong-Geug& Lee, Hye Won& Lee, Sung-Bae& Lee, Jin-Seok& Im, Hwi-Jin…[et al.]. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104190
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104190
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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