A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model
Joint Authors
Lee, Hye Won
Lee, Jin-Seok
Kim, Hyeong-Geug
Kim, Hyo-Seon
Lee, Sung-Bae
Im, Hwi-Jin
Kim, Won-Yong
Lee, Dong-Soo
Son, Chang Gue
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We aimed to evaluate the antihepatofibrotic effects of CGXII, an aqueous extract which is composed of A.
iwayomogi, A.
xanthioides, and S.
miltiorrhiza, against dimethylnitrosamine- (DMN-) induced hepatofibrosis.
Male Sprague Dawley rats were intraperitoneally injected with 10 mg/kg of DMN for 4 weeks (three consecutive days weekly).
Rats were orally given distilled water, CGXII (50 or 100 mg/kg), or dimethyl dimethoxy biphenyl dicarboxylate (50 mg/kg) daily.
DMN injection caused substantial alteration of total body weight and liver and spleen mass, whereas they were notably normalized by CGXII.
CGXII treatment also markedly attenuated the elevation of serum aspartate aminotransferase and alanine aminotransferase levels, hepatic lipid peroxidation, and protein carbonyl contents.
Collagen accumulation in hepatic tissue evidenced by histopathological analysis and quantitative assessment of hepatic hydroxyproline was ameliorated by CGXII.
Immunohistochemistry analysis revealed decreased α-smooth muscle actin supporting the antihepatofibrotic effect of CGXII.
The profibrogenic cytokines transforming growth factor-β, platelet-derived growth factor-β, and connective tissue growth factor were increased by DMN injection.
Administration of CGXII normalized the protein and gene expression levels of these cytokines.
Our findings suggest that CGXII lowers the levels of profibrogenic cytokines and thereby exerts antifibrotic effects.
American Psychological Association (APA)
Kim, Hyo-Seon& Kim, Hyeong-Geug& Lee, Hye Won& Lee, Sung-Bae& Lee, Jin-Seok& Im, Hwi-Jin…[et al.]. 2016. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104190
Modern Language Association (MLA)
Kim, Hyo-Seon…[et al.]. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1104190
American Medical Association (AMA)
Kim, Hyo-Seon& Kim, Hyeong-Geug& Lee, Hye Won& Lee, Sung-Bae& Lee, Jin-Seok& Im, Hwi-Jin…[et al.]. A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104190