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Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells
المؤلفون المشاركون
Tang, Min-Ke
Fan, Yue
Qiao, Yuan
Huang, J.-M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Diabetic retinopathy, a leading cause of visual loss and blindness, is characterized by microvascular dysfunction.
Hyperglycemia is considered the major pathogenic factor for diabetic retinopathy and is associated with increased oxidative stress in the retina.
In this study, we investigated the potential protective effects of Panax notoginseng Saponins (PNS) in retinal capillary endothelial cells (RCECs) exposed to high glucose conditions.
We found a pronounced increase in cell viability in rat RCECs incubated with both PNS and high glucose (30 mM) for 48 h or 72 h.
The increased viability was accompanied by reduced intracellular hydrogen peroxide ( H 2 O 2 ) and superoxide ( O 2 - ), decreased mitochondrial reactive oxygen species (ROS), and lowered malondialdehyde (MDA) levels.
PNS also increased the activities of total superoxide dismutase (SOD), MnSOD, catalase (CAT), and glutathione peroxidase (GSH-PX).
The glutathione (GSH) content also increased after PNS treatment.
Furthermore, PNS reduced NADPH oxidase 4 (Nox4) expression.
These results indicate that PNS exerts a protective effect against high glucose-induced injury in RCECs, which may be partially attributed to its antioxidative function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Yue& Qiao, Yuan& Huang, J.-M.& Tang, Min-Ke. 2016. Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104202
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Yue…[et al.]. Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104202
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Yue& Qiao, Yuan& Huang, J.-M.& Tang, Min-Ke. Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104202
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104202
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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