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Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells
Joint Authors
Tang, Min-Ke
Fan, Yue
Qiao, Yuan
Huang, J.-M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic retinopathy, a leading cause of visual loss and blindness, is characterized by microvascular dysfunction.
Hyperglycemia is considered the major pathogenic factor for diabetic retinopathy and is associated with increased oxidative stress in the retina.
In this study, we investigated the potential protective effects of Panax notoginseng Saponins (PNS) in retinal capillary endothelial cells (RCECs) exposed to high glucose conditions.
We found a pronounced increase in cell viability in rat RCECs incubated with both PNS and high glucose (30 mM) for 48 h or 72 h.
The increased viability was accompanied by reduced intracellular hydrogen peroxide ( H 2 O 2 ) and superoxide ( O 2 - ), decreased mitochondrial reactive oxygen species (ROS), and lowered malondialdehyde (MDA) levels.
PNS also increased the activities of total superoxide dismutase (SOD), MnSOD, catalase (CAT), and glutathione peroxidase (GSH-PX).
The glutathione (GSH) content also increased after PNS treatment.
Furthermore, PNS reduced NADPH oxidase 4 (Nox4) expression.
These results indicate that PNS exerts a protective effect against high glucose-induced injury in RCECs, which may be partially attributed to its antioxidative function.
American Psychological Association (APA)
Fan, Yue& Qiao, Yuan& Huang, J.-M.& Tang, Min-Ke. 2016. Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104202
Modern Language Association (MLA)
Fan, Yue…[et al.]. Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104202
American Medical Association (AMA)
Fan, Yue& Qiao, Yuan& Huang, J.-M.& Tang, Min-Ke. Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104202