Salvianolate Protects Hepatocytes from Oxidative Stress by Attenuating Mitochondrial Injury
المؤلفون المشاركون
Peng, Yuan
Tao, Yanyan
Liu, Chenghai
Zhao, Qiang
Huang, Kai
Lei, Yang
Liu, Hong-Liang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Salvianolate is widely used to treat angiocardiopathy in clinic in China, but its application in liver diseases remains unclear.
Our study aims to investigate the effect of Salvianolate on rat hepatic injury by protecting hepatocyte mitochondria.
To evaluate the effects of Salvianolate on injured hepatocytes, alpha mouse liver 12 (AML-12) cells were induced with hydrogen peroxide (H2O2) and treated with Salvianolate.
Cell viability and MitoTracker Green for mitochondria and 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazole-carbocyanide iodine (JC-1) levels and cytochrome C (Cyto-C) expressions were detected in vitro.
To identify the effect of Salvianolate on protecting against mitochondria injury, male Wistar rats were injected with carbon tetrachloride (CCl4) and treated with Salvianolate (40 mg·kg−1).
Serum liver function, parameters for peroxidative damage, hematoxylin and eosin (H&E) staining, and transmission electron microscope (TEM) of hepatocyte mitochondria were assayed.
Our results showed that Salvianolate effectively protected hepatocytes, increased mitochondria vitality, and decreased Cyto-C expressions in vitro.
Besides, Salvianolate alleviated the liver function, attenuated the indicators of peroxidation, and relieved the mitochondria injury in vivo.
In conclusion, Salvianolate is effective in protecting hepatocytes from injury in vitro and in vivo, and the mechanism might be related to its protective effect on hepatocyte mitochondria against oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Qiang& Peng, Yuan& Huang, Kai& Lei, Yang& Liu, Hong-Liang& Tao, Yanyan…[et al.]. 2016. Salvianolate Protects Hepatocytes from Oxidative Stress by Attenuating Mitochondrial Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104210
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Qiang…[et al.]. Salvianolate Protects Hepatocytes from Oxidative Stress by Attenuating Mitochondrial Injury. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104210
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Qiang& Peng, Yuan& Huang, Kai& Lei, Yang& Liu, Hong-Liang& Tao, Yanyan…[et al.]. Salvianolate Protects Hepatocytes from Oxidative Stress by Attenuating Mitochondrial Injury. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104210
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104210
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر