Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model
المؤلفون المشاركون
Xie, Shu-wu
Zhu, Yan
Zhong, Ruihua
Ma, Aying
Zhu, Jianping
Li, Guoting
Li, Zhao
Gui, Youlun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We evaluated the effectiveness of Kuntai Capsule (KTC) for treating endometriosis using rat model and investigated its preliminary mechanism of action involved.
SD rats were implanted with endometrial tissues and treated with KTC for three weeks.
Then, laparotomy was performed to examine volume changes of the autografts.
The serum levels of TNF-α, IL-6, COX-2, E2, and P4 were measured through ELISA.
TUNEL was performed to analyze the apoptosis on ectopic endometrium.
Protein levels of caspases 8, 9, and 3 and cytochrome c in the ectopic and eutopic endometrium were measured by western blotting.
Results showed that KTC significantly decreased the volumes of ectopic endometrium.
The level of TNF-α increased and E2 decreased in the KTC treatment groups.
TUNEL and western blot assay showed that KTC could induce apoptosis of endometriotic tissues, accompanied with the increased protein expression of caspases 8 and 9, activated caspase-3, and cytochrome c in a dose-dependent manner.
However, these protein expression profiles were not affected in eutopic endometrium.
Our findings suggest that KTC could inhibit the growth of ectopic endometrial tissue through upregulating the level of TNF-α and its downstream signaling, including caspases and cytochrome c.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Ruihua& Ma, Aying& Zhu, Jianping& Li, Guoting& Xie, Shu-wu& Li, Zhao…[et al.]. 2016. Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104220
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Ruihua…[et al.]. Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104220
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Ruihua& Ma, Aying& Zhu, Jianping& Li, Guoting& Xie, Shu-wu& Li, Zhao…[et al.]. Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104220
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104220
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر