![](/images/graphics-bg.png)
Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model
Joint Authors
Xie, Shu-wu
Zhu, Yan
Zhong, Ruihua
Ma, Aying
Zhu, Jianping
Li, Guoting
Li, Zhao
Gui, Youlun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We evaluated the effectiveness of Kuntai Capsule (KTC) for treating endometriosis using rat model and investigated its preliminary mechanism of action involved.
SD rats were implanted with endometrial tissues and treated with KTC for three weeks.
Then, laparotomy was performed to examine volume changes of the autografts.
The serum levels of TNF-α, IL-6, COX-2, E2, and P4 were measured through ELISA.
TUNEL was performed to analyze the apoptosis on ectopic endometrium.
Protein levels of caspases 8, 9, and 3 and cytochrome c in the ectopic and eutopic endometrium were measured by western blotting.
Results showed that KTC significantly decreased the volumes of ectopic endometrium.
The level of TNF-α increased and E2 decreased in the KTC treatment groups.
TUNEL and western blot assay showed that KTC could induce apoptosis of endometriotic tissues, accompanied with the increased protein expression of caspases 8 and 9, activated caspase-3, and cytochrome c in a dose-dependent manner.
However, these protein expression profiles were not affected in eutopic endometrium.
Our findings suggest that KTC could inhibit the growth of ectopic endometrial tissue through upregulating the level of TNF-α and its downstream signaling, including caspases and cytochrome c.
American Psychological Association (APA)
Zhong, Ruihua& Ma, Aying& Zhu, Jianping& Li, Guoting& Xie, Shu-wu& Li, Zhao…[et al.]. 2016. Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104220
Modern Language Association (MLA)
Zhong, Ruihua…[et al.]. Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104220
American Medical Association (AMA)
Zhong, Ruihua& Ma, Aying& Zhu, Jianping& Li, Guoting& Xie, Shu-wu& Li, Zhao…[et al.]. Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104220