Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERKP53 Pathway
المؤلفون المشاركون
Qin, Meng
Sun, Guibo
Cui, Xiaolan
Meng, Xiangbao
Sun, Xiaobo
Sun, Jing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-14
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Doxorubicin (Dox) is one of the most effective and widely used anthracycline antineoplastic antibiotics.
Unfortunately, the use of Dox is limited by its cumulative and dose-dependent cardiac toxicity.
Myricitrin, a natural flavonoid which is isolated from the ground bark of Myrica rubra, has recently been found to have a strong antioxidative effect.
This study aimed to evaluate the possible protective effect of myricitrin against Dox-induced cardiotoxicity and the underlying mechanisms.
An in vivo investigation in SD rats demonstrated that myricitrin significantly reduced the Dox-induced myocardial damage, as indicated by the decreases in the cardiac index, amelioration of heart pathological injuries, and decreases in the serum cardiac enzyme levels.
In addition, in vitro studies showed that myricitrin effectively reduced the Dox-induced cell toxicity.
Further study showed that myricitrin exerted its function by counteracting oxidative stress and increasing the activities of antioxidant enzymes.
Moreover, myricitrin suppressed the myocardial apoptosis induced by Dox, as indicated by decreases in the activation of caspase-3 and the numbers of TUNEL-positive cells, maintenance of the mitochondrial membrane potential, and increase in the Bcl-2/Bax ratio.
Further mechanism study revealed that myricitrin-induced suppression of myocardial apoptosis relied on the ERK/p53-mediated mitochondrial apoptosis pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Jing& Sun, Guibo& Cui, Xiaolan& Meng, Xiangbao& Qin, Meng& Sun, Xiaobo. 2016. Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERKP53 Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1104265
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Jing…[et al.]. Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERKP53 Pathway. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1104265
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Jing& Sun, Guibo& Cui, Xiaolan& Meng, Xiangbao& Qin, Meng& Sun, Xiaobo. Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERKP53 Pathway. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1104265
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104265
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر