Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERKP53 Pathway
Joint Authors
Qin, Meng
Sun, Guibo
Cui, Xiaolan
Meng, Xiangbao
Sun, Xiaobo
Sun, Jing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-14
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Doxorubicin (Dox) is one of the most effective and widely used anthracycline antineoplastic antibiotics.
Unfortunately, the use of Dox is limited by its cumulative and dose-dependent cardiac toxicity.
Myricitrin, a natural flavonoid which is isolated from the ground bark of Myrica rubra, has recently been found to have a strong antioxidative effect.
This study aimed to evaluate the possible protective effect of myricitrin against Dox-induced cardiotoxicity and the underlying mechanisms.
An in vivo investigation in SD rats demonstrated that myricitrin significantly reduced the Dox-induced myocardial damage, as indicated by the decreases in the cardiac index, amelioration of heart pathological injuries, and decreases in the serum cardiac enzyme levels.
In addition, in vitro studies showed that myricitrin effectively reduced the Dox-induced cell toxicity.
Further study showed that myricitrin exerted its function by counteracting oxidative stress and increasing the activities of antioxidant enzymes.
Moreover, myricitrin suppressed the myocardial apoptosis induced by Dox, as indicated by decreases in the activation of caspase-3 and the numbers of TUNEL-positive cells, maintenance of the mitochondrial membrane potential, and increase in the Bcl-2/Bax ratio.
Further mechanism study revealed that myricitrin-induced suppression of myocardial apoptosis relied on the ERK/p53-mediated mitochondrial apoptosis pathway.
American Psychological Association (APA)
Sun, Jing& Sun, Guibo& Cui, Xiaolan& Meng, Xiangbao& Qin, Meng& Sun, Xiaobo. 2016. Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERKP53 Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1104265
Modern Language Association (MLA)
Sun, Jing…[et al.]. Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERKP53 Pathway. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1104265
American Medical Association (AMA)
Sun, Jing& Sun, Guibo& Cui, Xiaolan& Meng, Xiangbao& Qin, Meng& Sun, Xiaobo. Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERKP53 Pathway. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1104265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104265