Ginsenoside Rg3 Improves Cardiac Function after Myocardial IschemiaReperfusion via Attenuating Apoptosis and Inflammation
المؤلفون المشاركون
Zhang, Li-ping
Jiang, Yi-chuan
Yu, Xiao-feng
Xu, Hua-li
Li, Min
Zhao, Xue-zhong
Sui, Da-yuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
Ginsenoside Rg3 is one of the ginsenosides which are the main constituents isolated from Panax ginseng.
Previous study demonstrated that ginsenoside Rg3 had a protective effect against myocardial ischemia/reperfusion- (I/R-) induced injury.
Objective.
This study was designed to evaluate the effect of ginsenoside Rg3 on cardiac function impairment induced by myocardial I/R in rats.
Methods.
Sprague-Dawley rats were subjected to myocardial I/R.
Echocardiographic and hemodynamic parameters and histopathological examination were carried out.
The expressions of P53, Bcl-2, Bax, and cleaved caspase-3 and the levels of TNF-α and IL-1β in the left ventricles were measured.
Results.
Ginsenoside Rg3 increased a left ventricular fractional shortening and left ventricular ejection fraction.
Treatment with ginsenoside Rg3 also alleviated increases of left ventricular end diastolic pressure and decreases of left ventricular systolic pressure and ±dp/dt in myocardial I/R-rats.
Ginsenoside Rg3 decreased apoptosis cells through inhibiting the activation of caspase-3.
Ginsenoside Rg3 also caused significant reductions of the contents of TNF-α and IL-1β in left ventricles of myocardial I/R-rats.
Conclusion.
The findings suggested that ginsenoside Rg3 possessed the effect of improving myocardial I/R-induced cardiac function impairment and that the mechanism of pharmacological action of ginsenoside Rg3 was related to its properties of antiapoptosis and anti-inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Li-ping& Jiang, Yi-chuan& Yu, Xiao-feng& Xu, Hua-li& Li, Min& Zhao, Xue-zhong…[et al.]. 2016. Ginsenoside Rg3 Improves Cardiac Function after Myocardial IschemiaReperfusion via Attenuating Apoptosis and Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104312
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Li-ping…[et al.]. Ginsenoside Rg3 Improves Cardiac Function after Myocardial IschemiaReperfusion via Attenuating Apoptosis and Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104312
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Li-ping& Jiang, Yi-chuan& Yu, Xiao-feng& Xu, Hua-li& Li, Min& Zhao, Xue-zhong…[et al.]. Ginsenoside Rg3 Improves Cardiac Function after Myocardial IschemiaReperfusion via Attenuating Apoptosis and Inflammation. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104312
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104312
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر