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Ginsenoside Rg3 Improves Cardiac Function after Myocardial IschemiaReperfusion via Attenuating Apoptosis and Inflammation
Joint Authors
Zhang, Li-ping
Jiang, Yi-chuan
Yu, Xiao-feng
Xu, Hua-li
Li, Min
Zhao, Xue-zhong
Sui, Da-yuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
Ginsenoside Rg3 is one of the ginsenosides which are the main constituents isolated from Panax ginseng.
Previous study demonstrated that ginsenoside Rg3 had a protective effect against myocardial ischemia/reperfusion- (I/R-) induced injury.
Objective.
This study was designed to evaluate the effect of ginsenoside Rg3 on cardiac function impairment induced by myocardial I/R in rats.
Methods.
Sprague-Dawley rats were subjected to myocardial I/R.
Echocardiographic and hemodynamic parameters and histopathological examination were carried out.
The expressions of P53, Bcl-2, Bax, and cleaved caspase-3 and the levels of TNF-α and IL-1β in the left ventricles were measured.
Results.
Ginsenoside Rg3 increased a left ventricular fractional shortening and left ventricular ejection fraction.
Treatment with ginsenoside Rg3 also alleviated increases of left ventricular end diastolic pressure and decreases of left ventricular systolic pressure and ±dp/dt in myocardial I/R-rats.
Ginsenoside Rg3 decreased apoptosis cells through inhibiting the activation of caspase-3.
Ginsenoside Rg3 also caused significant reductions of the contents of TNF-α and IL-1β in left ventricles of myocardial I/R-rats.
Conclusion.
The findings suggested that ginsenoside Rg3 possessed the effect of improving myocardial I/R-induced cardiac function impairment and that the mechanism of pharmacological action of ginsenoside Rg3 was related to its properties of antiapoptosis and anti-inflammation.
American Psychological Association (APA)
Zhang, Li-ping& Jiang, Yi-chuan& Yu, Xiao-feng& Xu, Hua-li& Li, Min& Zhao, Xue-zhong…[et al.]. 2016. Ginsenoside Rg3 Improves Cardiac Function after Myocardial IschemiaReperfusion via Attenuating Apoptosis and Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104312
Modern Language Association (MLA)
Zhang, Li-ping…[et al.]. Ginsenoside Rg3 Improves Cardiac Function after Myocardial IschemiaReperfusion via Attenuating Apoptosis and Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104312
American Medical Association (AMA)
Zhang, Li-ping& Jiang, Yi-chuan& Yu, Xiao-feng& Xu, Hua-li& Li, Min& Zhao, Xue-zhong…[et al.]. Ginsenoside Rg3 Improves Cardiac Function after Myocardial IschemiaReperfusion via Attenuating Apoptosis and Inflammation. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104312