![](/images/graphics-bg.png)
Effects of Huang Qi Decoction on Endothelial Dysfunction Induced by Homocysteine
المؤلفون المشاركون
Chu, Shuang
Mao, Xiao-dong
Wang, Li
Peng, Wen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Vascular endothelial dysfunction can be induced by homocysteine (Hcy) through promoted oxidative stress.
Huang Qi decoction (HQD) is a traditional Chinese medical formula and its components possess antioxidant effect.
The study herein was therefore designed to investigate the effects of HQD at different dosage on endothelial dysfunction induced by Hcy.
Tempol and apocynin were used to investigate whether antioxidant mechanisms were involved.
Endothelium-dependent relaxation of rat aortas was investigated by isometric tension recordings.
Reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVECs) was determined by DHE staining.
The assessment related to oxidative stress and NO bioavailability was performed by assay kits and western blot.
In isometric tension experiment, HQD at the dose of 30 or 100 μg/mL, tempol, or apocynin prevented impaired endothelium-dependent relaxation in isolated aortas elicited by Hcy.
In cellular experiments, substantial enhancement in NADPH oxidase and ROS generation and reduction in NO bioavailability triggered by Hcy were reversed by pretreatment of HQD at the dose of 100 μg/mL, tempol, or apocynin.
The results proved that HQD at an appropriate dosage presented favorable effects on endothelial dysfunction initiated by Hcy through antioxidant mechanisms.
HQD can act as a potent prescription for the treatment of endothelium related vascular complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chu, Shuang& Mao, Xiao-dong& Wang, Li& Peng, Wen. 2016. Effects of Huang Qi Decoction on Endothelial Dysfunction Induced by Homocysteine. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104333
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chu, Shuang…[et al.]. Effects of Huang Qi Decoction on Endothelial Dysfunction Induced by Homocysteine. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104333
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chu, Shuang& Mao, Xiao-dong& Wang, Li& Peng, Wen. Effects of Huang Qi Decoction on Endothelial Dysfunction Induced by Homocysteine. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104333
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104333
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)