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Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites
المؤلفون المشاركون
Abdullah, Rasedee
Ismail, Maznah
Mohd Tohit, Eusni Rahayu
Wong, Waiteng
Zhang, Yi-Da
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Vascular occlusion or thrombosis was often attributed to uncontrolled platelet activation.
Influence of sugarcane policosanol extract on platelet was reported but little was known of rice bran policosanol, particularly its mechanisms of actions on platelet activities.
Objective.
Antiplatelet mechanisms of rice bran policosanol extract (RBE) were studied using hyperlipidemic Sprague Dawley rats.
Ex vivo platelet aggregation, platelet count (PC), bleeding time (BT), and coagulation time were assayed.
Serum eicosanoids and other aggregation-related metabolites levels were quantified.
Design.
Rats were divided into 6 groups for comparisons (vehicle control Tween 20/H2O, high dose policosanol 500 mg/kg, middle dose policosanol 250 mg/kg, low dose policosanol 100 mg/kg, and positive control aspirin 30 mg/kg).
Results.
Low dose 100 mg/kg of RBE inhibited aggregation by 42.32 ± 4.31 % and this was comparable with the effect of 30 mg/kg aspirin, 43.91 ± 5.27 %.
Results showed that there were no significant differences in PC, BT, and coagulation time among various groups after RBE treatment.
Serum thromboxane A2 was attenuated while prostacyclin level increased upon RBE treatment.
Conclusions.
RBE reduced ex vivo ADP-induced platelet aggregation without giving adverse effects.
No changes in full blood count suggested that rice bran policosanol did not disturb biological blood cell production and destruction yet it reduced aggregation through different mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wong, Waiteng& Ismail, Maznah& Mohd Tohit, Eusni Rahayu& Abdullah, Rasedee& Zhang, Yi-Da. 2016. Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104343
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wong, Waiteng…[et al.]. Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104343
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wong, Waiteng& Ismail, Maznah& Mohd Tohit, Eusni Rahayu& Abdullah, Rasedee& Zhang, Yi-Da. Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104343
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104343
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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