Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites
Joint Authors
Abdullah, Rasedee
Ismail, Maznah
Mohd Tohit, Eusni Rahayu
Wong, Waiteng
Zhang, Yi-Da
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Vascular occlusion or thrombosis was often attributed to uncontrolled platelet activation.
Influence of sugarcane policosanol extract on platelet was reported but little was known of rice bran policosanol, particularly its mechanisms of actions on platelet activities.
Objective.
Antiplatelet mechanisms of rice bran policosanol extract (RBE) were studied using hyperlipidemic Sprague Dawley rats.
Ex vivo platelet aggregation, platelet count (PC), bleeding time (BT), and coagulation time were assayed.
Serum eicosanoids and other aggregation-related metabolites levels were quantified.
Design.
Rats were divided into 6 groups for comparisons (vehicle control Tween 20/H2O, high dose policosanol 500 mg/kg, middle dose policosanol 250 mg/kg, low dose policosanol 100 mg/kg, and positive control aspirin 30 mg/kg).
Results.
Low dose 100 mg/kg of RBE inhibited aggregation by 42.32 ± 4.31 % and this was comparable with the effect of 30 mg/kg aspirin, 43.91 ± 5.27 %.
Results showed that there were no significant differences in PC, BT, and coagulation time among various groups after RBE treatment.
Serum thromboxane A2 was attenuated while prostacyclin level increased upon RBE treatment.
Conclusions.
RBE reduced ex vivo ADP-induced platelet aggregation without giving adverse effects.
No changes in full blood count suggested that rice bran policosanol did not disturb biological blood cell production and destruction yet it reduced aggregation through different mechanisms.
American Psychological Association (APA)
Wong, Waiteng& Ismail, Maznah& Mohd Tohit, Eusni Rahayu& Abdullah, Rasedee& Zhang, Yi-Da. 2016. Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104343
Modern Language Association (MLA)
Wong, Waiteng…[et al.]. Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104343
American Medical Association (AMA)
Wong, Waiteng& Ismail, Maznah& Mohd Tohit, Eusni Rahayu& Abdullah, Rasedee& Zhang, Yi-Da. Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104343