Chitosan and Sodium Alginate Combinations Are Alternative, Efficient, and Safe Natural Adjuvant Systems for Hepatitis B Vaccine in Mouse Model
المؤلفون المشاركون
Amin, Magdy A.
AbdelAllah, Nourhan H.
Abdeltawab, Nourtan F.
Boseila, Abeer A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Hepatitis B viral (HBV) infections represent major public health problem and are an occupational hazard for healthcare workers.
Current alum-adjuvanted HBV vaccine is the most effective measure to prevent HBV infection.
However, the vaccine has some limitations including poor response in some vaccinee and being a frost-sensitive suspension.
The goal of our study was to use an alternative natural adjuvant system strongly immunogenic allowing for a reduction in dose and cost.
We tested HBV surface antigen (HBsAg) adjuvanted with chitosan (Ch) and sodium alginate (S), both natural adjuvants, either alone or combined with alum in mouse model.
Mice groups were immunized subcutaneously with HBsAg adjuvanted with Ch or S, or triple adjuvant formula with alum (Al), Ch, and S, or double formulations with AlCh or AlS.
These were compared to control groups immunized with current vaccine formula or unadjuvanted HBsAg.
We evaluated the rate of seroconversion, serum HBsAg antibody, IL-4, and IFN-γ levels.
The results showed that the solution formula with Ch or S exhibited comparable immunogenic responses to Al-adjuvanted suspension.
The AlChS gave significantly higher immunogenic response compared to controls.
Collectively, our results indicated that Ch and S are effective HBV adjuvants offering natural alternatives, potentially reducing dose.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
AbdelAllah, Nourhan H.& Abdeltawab, Nourtan F.& Boseila, Abeer A.& Amin, Magdy A.. 2016. Chitosan and Sodium Alginate Combinations Are Alternative, Efficient, and Safe Natural Adjuvant Systems for Hepatitis B Vaccine in Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
AbdelAllah, Nourhan H.…[et al.]. Chitosan and Sodium Alginate Combinations Are Alternative, Efficient, and Safe Natural Adjuvant Systems for Hepatitis B Vaccine in Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
AbdelAllah, Nourhan H.& Abdeltawab, Nourtan F.& Boseila, Abeer A.& Amin, Magdy A.. Chitosan and Sodium Alginate Combinations Are Alternative, Efficient, and Safe Natural Adjuvant Systems for Hepatitis B Vaccine in Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر