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Chitosan and Sodium Alginate Combinations Are Alternative, Efficient, and Safe Natural Adjuvant Systems for Hepatitis B Vaccine in Mouse Model
Joint Authors
Amin, Magdy A.
AbdelAllah, Nourhan H.
Abdeltawab, Nourtan F.
Boseila, Abeer A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hepatitis B viral (HBV) infections represent major public health problem and are an occupational hazard for healthcare workers.
Current alum-adjuvanted HBV vaccine is the most effective measure to prevent HBV infection.
However, the vaccine has some limitations including poor response in some vaccinee and being a frost-sensitive suspension.
The goal of our study was to use an alternative natural adjuvant system strongly immunogenic allowing for a reduction in dose and cost.
We tested HBV surface antigen (HBsAg) adjuvanted with chitosan (Ch) and sodium alginate (S), both natural adjuvants, either alone or combined with alum in mouse model.
Mice groups were immunized subcutaneously with HBsAg adjuvanted with Ch or S, or triple adjuvant formula with alum (Al), Ch, and S, or double formulations with AlCh or AlS.
These were compared to control groups immunized with current vaccine formula or unadjuvanted HBsAg.
We evaluated the rate of seroconversion, serum HBsAg antibody, IL-4, and IFN-γ levels.
The results showed that the solution formula with Ch or S exhibited comparable immunogenic responses to Al-adjuvanted suspension.
The AlChS gave significantly higher immunogenic response compared to controls.
Collectively, our results indicated that Ch and S are effective HBV adjuvants offering natural alternatives, potentially reducing dose.
American Psychological Association (APA)
AbdelAllah, Nourhan H.& Abdeltawab, Nourtan F.& Boseila, Abeer A.& Amin, Magdy A.. 2016. Chitosan and Sodium Alginate Combinations Are Alternative, Efficient, and Safe Natural Adjuvant Systems for Hepatitis B Vaccine in Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104369
Modern Language Association (MLA)
AbdelAllah, Nourhan H.…[et al.]. Chitosan and Sodium Alginate Combinations Are Alternative, Efficient, and Safe Natural Adjuvant Systems for Hepatitis B Vaccine in Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104369
American Medical Association (AMA)
AbdelAllah, Nourhan H.& Abdeltawab, Nourtan F.& Boseila, Abeer A.& Amin, Magdy A.. Chitosan and Sodium Alginate Combinations Are Alternative, Efficient, and Safe Natural Adjuvant Systems for Hepatitis B Vaccine in Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104369