Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo
المؤلفون المشاركون
Tabassum, Nadia
Jung, Da-Woon
Williams, Darren R.
Lee, Ji-Hyung
Yim, Soon-Ho
Batkhuu, Galzad Javzan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
There is a continual need to develop novel and effective melanogenesis inhibitors for the prevention of hyperpigmentation disorders.
The plant Artemisia capillaris Thunberg (Oriental Wormwood) was screened for antipigmentation activity using murine cultured cells (B16-F10 malignant melanocytes).
Activity-based fractionation using HPLC and NMR analyses identified the compound 4,5- O -dicaffeoylquinic acid as an active component in this plant.
4,5- O -Dicaffeoylquinic acid significantly reduced melanin synthesis and tyrosinase activity in a dose-dependent manner in the melanocytes.
In addition, 4,5- O -dicaffeoylquinic acid treatment reduced the expression of tyrosinase-related protein-1.
Significantly, we could validate the antipigmentation activity of this compound in vivo, using a zebrafish model.
Moreover, 4,5- O -dicaffeoylquinic acid did not show toxicity in this animal model.
Our discovery of 4,5- O -dicaffeoylquinic acid as an inhibitor of pigmentation that is active in vivo shows that this compound can be developed as an active component for formulations to treat pigmentation disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tabassum, Nadia& Lee, Ji-Hyung& Yim, Soon-Ho& Batkhuu, Galzad Javzan& Jung, Da-Woon& Williams, Darren R.. 2016. Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tabassum, Nadia…[et al.]. Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tabassum, Nadia& Lee, Ji-Hyung& Yim, Soon-Ho& Batkhuu, Galzad Javzan& Jung, Da-Woon& Williams, Darren R.. Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر