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Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo
Joint Authors
Tabassum, Nadia
Jung, Da-Woon
Williams, Darren R.
Lee, Ji-Hyung
Yim, Soon-Ho
Batkhuu, Galzad Javzan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
There is a continual need to develop novel and effective melanogenesis inhibitors for the prevention of hyperpigmentation disorders.
The plant Artemisia capillaris Thunberg (Oriental Wormwood) was screened for antipigmentation activity using murine cultured cells (B16-F10 malignant melanocytes).
Activity-based fractionation using HPLC and NMR analyses identified the compound 4,5- O -dicaffeoylquinic acid as an active component in this plant.
4,5- O -Dicaffeoylquinic acid significantly reduced melanin synthesis and tyrosinase activity in a dose-dependent manner in the melanocytes.
In addition, 4,5- O -dicaffeoylquinic acid treatment reduced the expression of tyrosinase-related protein-1.
Significantly, we could validate the antipigmentation activity of this compound in vivo, using a zebrafish model.
Moreover, 4,5- O -dicaffeoylquinic acid did not show toxicity in this animal model.
Our discovery of 4,5- O -dicaffeoylquinic acid as an inhibitor of pigmentation that is active in vivo shows that this compound can be developed as an active component for formulations to treat pigmentation disorders.
American Psychological Association (APA)
Tabassum, Nadia& Lee, Ji-Hyung& Yim, Soon-Ho& Batkhuu, Galzad Javzan& Jung, Da-Woon& Williams, Darren R.. 2016. Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104374
Modern Language Association (MLA)
Tabassum, Nadia…[et al.]. Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104374
American Medical Association (AMA)
Tabassum, Nadia& Lee, Ji-Hyung& Yim, Soon-Ho& Batkhuu, Galzad Javzan& Jung, Da-Woon& Williams, Darren R.. Isolation of 4,5-O-Dicaffeoylquinic Acid as a Pigmentation Inhibitor Occurring in Artemisia capillaris Thunberg and Its Validation In Vivo. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104374