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Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition
المؤلفون المشاركون
Larson, Erica C.
Pond, Christopher D.
Rai, Prem P.
Matainaho, Teatulohi K.
Piskaut, Pius
Franklin, Michael R.
Barrows, Louis R.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The hypothesis underlying this current work is that fresh juice expressed from Papua New Guinea (PNG) medicinal plants (succus) will inhibit human Cytochrome P450s (CYPs).
The CYP inhibitory activity identified in fresh material was compared with inhibition in methanol extracts of dried material.
Succus is the most common method of traditional medicine (TM) preparation for consumption in PNG.
There is increasing concern that TMs might antagonize or complicate drug therapy.
We have previously shown that methanol extracts of commonly consumed PNG medicinal plants are able to induce and/or inhibit human CYPs in vitro.
In this current work plant succus was prepared from fresh plant leaves.
Inhibition of three major CYPs was determined using human liver microsomes and enzyme-selective model substrates.
Of 15 species tested, succus from 6/15 was found to inhibit CYP1A2, 7/15 inhibited CYP3A4, and 4/15 inhibited CYP2D6.
Chi-squared tests determined differences in inhibitory activity between succus and methanol preparations.
Over 80% agreement was found.
Thus, fresh juice from PNG medicinal plants does exhibit the potential to complicate drug therapy in at risk populations.
Further, the general reproducibility of these findings suggests that methanol extraction of dried material is a reasonable surrogate preparation method for fresh plant samples.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Larson, Erica C.& Pond, Christopher D.& Rai, Prem P.& Matainaho, Teatulohi K.& Piskaut, Pius& Franklin, Michael R.…[et al.]. 2016. Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Larson, Erica C.…[et al.]. Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1104381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Larson, Erica C.& Pond, Christopher D.& Rai, Prem P.& Matainaho, Teatulohi K.& Piskaut, Pius& Franklin, Michael R.…[et al.]. Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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