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Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition
Joint Authors
Larson, Erica C.
Pond, Christopher D.
Rai, Prem P.
Matainaho, Teatulohi K.
Piskaut, Pius
Franklin, Michael R.
Barrows, Louis R.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The hypothesis underlying this current work is that fresh juice expressed from Papua New Guinea (PNG) medicinal plants (succus) will inhibit human Cytochrome P450s (CYPs).
The CYP inhibitory activity identified in fresh material was compared with inhibition in methanol extracts of dried material.
Succus is the most common method of traditional medicine (TM) preparation for consumption in PNG.
There is increasing concern that TMs might antagonize or complicate drug therapy.
We have previously shown that methanol extracts of commonly consumed PNG medicinal plants are able to induce and/or inhibit human CYPs in vitro.
In this current work plant succus was prepared from fresh plant leaves.
Inhibition of three major CYPs was determined using human liver microsomes and enzyme-selective model substrates.
Of 15 species tested, succus from 6/15 was found to inhibit CYP1A2, 7/15 inhibited CYP3A4, and 4/15 inhibited CYP2D6.
Chi-squared tests determined differences in inhibitory activity between succus and methanol preparations.
Over 80% agreement was found.
Thus, fresh juice from PNG medicinal plants does exhibit the potential to complicate drug therapy in at risk populations.
Further, the general reproducibility of these findings suggests that methanol extraction of dried material is a reasonable surrogate preparation method for fresh plant samples.
American Psychological Association (APA)
Larson, Erica C.& Pond, Christopher D.& Rai, Prem P.& Matainaho, Teatulohi K.& Piskaut, Pius& Franklin, Michael R.…[et al.]. 2016. Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104381
Modern Language Association (MLA)
Larson, Erica C.…[et al.]. Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1104381
American Medical Association (AMA)
Larson, Erica C.& Pond, Christopher D.& Rai, Prem P.& Matainaho, Teatulohi K.& Piskaut, Pius& Franklin, Michael R.…[et al.]. Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104381