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Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo
المؤلفون المشاركون
Wu, Fei
Li, Yi
Song, Haibo
Zhang, Yuan
Zhang, Yuzhu
Jiang, Miao
Wang, Fang
Mu, Qian
Zhang, Wen
Li, Liang
Tang, Dongqi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Nephrotoxicity is a frequent severe side effect of cisplatin chemotherapy, limiting its clinical use despite being one of the most potent chemotherapy drugs.
Dihydromyricetin is a highly abundant compound purified from the leaves of Ampelopsis grossedentata.
Previous studies have demonstrated the anti-inflammatory and antioxidative effects of Dihydromyricetin both in vitro and in vivo, but little is known about the effects of Dihydromyricetin on cisplatin-induced nephrotoxicity and its underlying mechanisms.
In the present study, we investigated its potential renoprotective effect and found that Dihydromyricetin ameliorated the renal functional impairment and structural damage caused by cisplatin.
Moreover, Dihydromyricetin markedly attenuated cisplatin-induced oxidative stress, as well as protecting against cisplatin-induced inflammation and apoptotic cell death in mouse kidney tissues.
These results collectively highlight the potential of DMY as a rational renoprotective agent against cisplatin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Fei& Li, Yi& Song, Haibo& Zhang, Yuan& Zhang, Yuzhu& Jiang, Miao…[et al.]. 2016. Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104393
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Fei…[et al.]. Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104393
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Fei& Li, Yi& Song, Haibo& Zhang, Yuan& Zhang, Yuzhu& Jiang, Miao…[et al.]. Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104393
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104393
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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