Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo
Joint Authors
Wu, Fei
Li, Yi
Song, Haibo
Zhang, Yuan
Zhang, Yuzhu
Jiang, Miao
Wang, Fang
Mu, Qian
Zhang, Wen
Li, Liang
Tang, Dongqi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nephrotoxicity is a frequent severe side effect of cisplatin chemotherapy, limiting its clinical use despite being one of the most potent chemotherapy drugs.
Dihydromyricetin is a highly abundant compound purified from the leaves of Ampelopsis grossedentata.
Previous studies have demonstrated the anti-inflammatory and antioxidative effects of Dihydromyricetin both in vitro and in vivo, but little is known about the effects of Dihydromyricetin on cisplatin-induced nephrotoxicity and its underlying mechanisms.
In the present study, we investigated its potential renoprotective effect and found that Dihydromyricetin ameliorated the renal functional impairment and structural damage caused by cisplatin.
Moreover, Dihydromyricetin markedly attenuated cisplatin-induced oxidative stress, as well as protecting against cisplatin-induced inflammation and apoptotic cell death in mouse kidney tissues.
These results collectively highlight the potential of DMY as a rational renoprotective agent against cisplatin.
American Psychological Association (APA)
Wu, Fei& Li, Yi& Song, Haibo& Zhang, Yuan& Zhang, Yuzhu& Jiang, Miao…[et al.]. 2016. Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104393
Modern Language Association (MLA)
Wu, Fei…[et al.]. Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104393
American Medical Association (AMA)
Wu, Fei& Li, Yi& Song, Haibo& Zhang, Yuan& Zhang, Yuzhu& Jiang, Miao…[et al.]. Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104393