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Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats
المؤلفون المشاركون
Zhu, Yingli
Wang, Linyuan
Yang, Zhihui
Zhou, Jianyu
Zhang, Jianjun
Wang, Jingxia
Wang, Chun
Wang, Chenglong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Neuropathic pain remains as the most frequent cause of suffering and disability around the world.
The isomers paeoniflorin (PF) and albiflorin (AF) are major constituents extracted from the roots of Paeonia (P.) lactiflora Pall.
Neuroprotective effect of PF has been demonstrated in animal models of neuropathologies.
However, only a few studies are related to the biological activities of AF and no report has been published on analgesic properties of AF about neuropathic pain to date.
The aim of this study was to compare the effects of AF and PF against CCI-induced neuropathic pain in rat and explore the underlying mechanism.
We had found that both PF and AF could inhibit the activation of p38 mitogen-activated protein kinase (p38 MAPK) pathway in spinal microglia and subsequent upregulated proinflammatory cytokines (interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)).
AF further displayed remarkable effects on inhibiting the activation of astrocytes, suppressing the overelevated expression of phosphorylation of c-Jun N-terminal kinases (p-JNK) in astrocytes, and decreasing the content of chemokine CXCL1 in the spinal cord.
These results suggest that both PF and AF are potential therapeutic agents for neuropathic pain, which merit further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Jianyu& Wang, Linyuan& Wang, Jingxia& Wang, Chun& Yang, Zhihui& Wang, Chenglong…[et al.]. 2016. Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Jianyu…[et al.]. Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Jianyu& Wang, Linyuan& Wang, Jingxia& Wang, Chun& Yang, Zhihui& Wang, Chenglong…[et al.]. Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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