Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats
Joint Authors
Zhu, Yingli
Wang, Linyuan
Yang, Zhihui
Zhou, Jianyu
Zhang, Jianjun
Wang, Jingxia
Wang, Chun
Wang, Chenglong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Neuropathic pain remains as the most frequent cause of suffering and disability around the world.
The isomers paeoniflorin (PF) and albiflorin (AF) are major constituents extracted from the roots of Paeonia (P.) lactiflora Pall.
Neuroprotective effect of PF has been demonstrated in animal models of neuropathologies.
However, only a few studies are related to the biological activities of AF and no report has been published on analgesic properties of AF about neuropathic pain to date.
The aim of this study was to compare the effects of AF and PF against CCI-induced neuropathic pain in rat and explore the underlying mechanism.
We had found that both PF and AF could inhibit the activation of p38 mitogen-activated protein kinase (p38 MAPK) pathway in spinal microglia and subsequent upregulated proinflammatory cytokines (interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)).
AF further displayed remarkable effects on inhibiting the activation of astrocytes, suppressing the overelevated expression of phosphorylation of c-Jun N-terminal kinases (p-JNK) in astrocytes, and decreasing the content of chemokine CXCL1 in the spinal cord.
These results suggest that both PF and AF are potential therapeutic agents for neuropathic pain, which merit further investigation.
American Psychological Association (APA)
Zhou, Jianyu& Wang, Linyuan& Wang, Jingxia& Wang, Chun& Yang, Zhihui& Wang, Chenglong…[et al.]. 2016. Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104400
Modern Language Association (MLA)
Zhou, Jianyu…[et al.]. Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104400
American Medical Association (AMA)
Zhou, Jianyu& Wang, Linyuan& Wang, Jingxia& Wang, Chun& Yang, Zhihui& Wang, Chenglong…[et al.]. Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104400