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ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula
المؤلفون المشاركون
Wang, Yun
Zhang, Bai-xia
Li, Yanwen
Zhang, Yanling
Li, Zhiyong
Bi, Tian
He, Yusu
Song, Kuokui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Identification of bioactive components is an important area of research in traditional Chinese medicine (TCM) formula.
The reported identification methods only consider the interaction between the components and the target proteins, which is not sufficient to explain the influence of TCM on the gene expression.
Here, we propose the Initial Transcription Process-based Identification (ITPI) method for the discovery of bioactive components that influence transcription factors (TFs).
In this method, genome-wide chip detection technology was used to identify differentially expressed genes (DEGs).
The TFs of DEGs were derived from GeneCards.
The components influencing the TFs were derived from STITCH.
The bioactive components in the formula were identified by evaluating the molecular similarity between the components in formula and the components that influence the TF of DEGs.
Using the formula of Tian-Zhu-San (TZS) as an example, the reliability and limitation of ITPI were examined and 16 bioactive components that influence TFs were identified.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Bai-xia& Li, Yanwen& Zhang, Yanling& Li, Zhiyong& Bi, Tian& He, Yusu…[et al.]. 2016. ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104416
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Bai-xia…[et al.]. ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104416
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Bai-xia& Li, Yanwen& Zhang, Yanling& Li, Zhiyong& Bi, Tian& He, Yusu…[et al.]. ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104416
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104416
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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