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ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula
Joint Authors
Wang, Yun
Zhang, Bai-xia
Li, Yanwen
Zhang, Yanling
Li, Zhiyong
Bi, Tian
He, Yusu
Song, Kuokui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Identification of bioactive components is an important area of research in traditional Chinese medicine (TCM) formula.
The reported identification methods only consider the interaction between the components and the target proteins, which is not sufficient to explain the influence of TCM on the gene expression.
Here, we propose the Initial Transcription Process-based Identification (ITPI) method for the discovery of bioactive components that influence transcription factors (TFs).
In this method, genome-wide chip detection technology was used to identify differentially expressed genes (DEGs).
The TFs of DEGs were derived from GeneCards.
The components influencing the TFs were derived from STITCH.
The bioactive components in the formula were identified by evaluating the molecular similarity between the components in formula and the components that influence the TF of DEGs.
Using the formula of Tian-Zhu-San (TZS) as an example, the reliability and limitation of ITPI were examined and 16 bioactive components that influence TFs were identified.
American Psychological Association (APA)
Zhang, Bai-xia& Li, Yanwen& Zhang, Yanling& Li, Zhiyong& Bi, Tian& He, Yusu…[et al.]. 2016. ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104416
Modern Language Association (MLA)
Zhang, Bai-xia…[et al.]. ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104416
American Medical Association (AMA)
Zhang, Bai-xia& Li, Yanwen& Zhang, Yanling& Li, Zhiyong& Bi, Tian& He, Yusu…[et al.]. ITPI: Initial Transcription Process-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104416